Expression of BAP1 and ATM proteins: Association with AJCC tumor category in uveal melanoma.

Jayanti Jha,Mithalesh Kumar Singh,Lata Singh,Neelam Pushker,Mandeep Singh Bajaj,Seema Sen,Seema Kashyap

Annals of Diagnostic Pathology（2020）

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摘要

•BAP1 and ATM proteins trigger DNA damage response (DDR) which leads to DNA repair.•ATM modifies the BAP1for the activation of DNA repair which signifies that there is a connecting link between ATM and BAP1.•Our findings demonstrate the synergistic role of ATM and BAP1 proteins and may have a therapeutic potential in uveal melanoma.

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关键词

Uveal Melanoma,BAP1,ATM,Co-expression,Immunohistochemistry,AJCC tumor category

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