Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.

Toshinobu Nishimura,Ian Hsu,Daniel C Martinez-Krams,Yusuke Nakauchi,Ravindra Majeti,Satoshi Yamazaki,Hiromitsu Nakauchi,Adam C Wilkinson

Experimental Hematology（2019）

引用 12|浏览32

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摘要

•Polyvinyl alcohol (PVA) stabilizes recombinant cytokines in liquid media.•PVA supports albumin-free growth of cytokine-dependent leukemia cells.•PVA can replace serum albumin for ex vivo expansion of functional CAR T cells.

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