Identification Of Circulating Microrna Signatures As Potential Noninvasive Biomarkers For Prediction To Response To Extracorporeal Photoapheresis In Patients With Graft Versus Host Disease

INTRODUCTION: Extracorporeal photoapheresis (ECP) is an immunomodulatory therapy for patients with acute or chronic graft-versus-host disease (aGVHD/cGVHD). So far, few studies have explored the molecular regulation of GVHD, and to date no studies have addressed how specific is miRNA expression change during ECP, and whether selected miRNA profiles might be predictive of clinical responses to ECP.