Haploidentical Stem Cell Transplantation In Advanced Stage Mycosis Fungoides And Sezary Syndrome: A Report Of Four Consecutive Cases From A Single Center

Introduction: In patients with advanced stage mycosis fungoides (MF) and Sézary syndrome (SS), allogeneic hematopoietic stem cell transplantation (allo-HSCT) continues to represent the only potentially curative treatment strategy. We have previously reported long-term outcome of our reduced intensity conditioning-based allo-HSCT program in MF and SS, including 38 patients who consecutively underwent transplantation from matched sibling or unrelated donor in the 2001-2018 time interval, with a 5-yr overall and disease-free survivals of 52% and 43%, respectively, and a 1-yr non relapse mortality of 17% (ASH annual meeting, 2018). In the most recent years, haploidentical donors are considered an increasing valid alternative for patients with haematological malignancies lacking a suitable matched donor. Here we report the results of our first series of haploidentical SCT (haplo-HSCT) in patients witn MF and SS.