Identification of Neurotoxicity Markers Induced by Realgar Exposure in the Mouse Cerebral Cortex Using Lipidomics

•Nontargeted lipidomics was first used to detect the changes of lipid levels in realgar exposure mice model.•A total of 34 lipid subclasses including 1603 lipid molecules were detected in the cerebral cortex of mice.•The LPE, LPC, PE, PC, and PS lipid subclasses were related to neurotoxicity induced by realgar.•The SM (d36:2), PE (18:2/22:6) and PE (36:3) could be used as early sensitive markers of neurotoxicity induced by realgar.•It was first reported that realgar induced neurotoxicity by decreasing SOD and increasing MDA.