Antibody response of goats to gel based combined vaccine against Peste des Petits Ruminants, Contagious Caprine Pleuropneumonia and Foot and Mouth Disease.

Present study was designed to prepare and evaluate gel based combined vaccine against Peste des Petits Ruminants (PPR), Contagious Caprine Pleuropneumonia (CCPP), Foot and Mouth Disease "O serotype" (FMDO) to mitigate the cost and frequency of the vaccination. Gel based vaccines contain either single immunogen (monovalent) of PPR, CCPP or FMDO, two (bivalent) PPR+FMDO, PPR+CCPP, FMDO+CCPPP or three (trivalent) PPR+CCPP+FMDO. Each dose (0.5 ml) of either of the vaccines contained 10(5) tissue culture infective dose (TCID50) units of FMDO virus, 10(7) TCID50 units of PPR virus and 0.15 mg of Mycoplasma mycoides capri. Each of the vaccine was injected subcutaneously to each of the goats (n=4). Antibody response of goats to FMDO, PPR and CCPP was determined by complement fixation test (CFT), virus neutralization test (VNT) and enzyme linked immunosorbant assay (ELISA), respectively at 0, 60, 120 and 180 days post-priming. Antibody response of the goats to either of the immunogen was not significantly different irrespective to the form of vaccine (monovalent, bivalent or multivalent vaccine) (P>0.05). It indicated that either of the immunogen did not interfere the immunogenesis process of other immunogens in the same vaccine.