Abnormal pain sensation in mice lacking the prokineticin receptor PKR2: interaction of PKR2 with transient receptor potential TRPV1 and TRPA1.
Neuroscience(2020)
摘要
•Pkr2-null mice are less responsive to noxious thermal hot and cold stimuli compared to wild type littermates.•Pkr2-null mice are less responsive to noxious chemical stimuli compared to wild type littermates.•Pkr2-null mice are less sensitive to inflammatory-induced heat hyperalgesia compared to wild type littermates.•Pkr2-null mice do not develop inflammatory-induced tactile allodynia.•PKR2 functionally interacts with TRP channels contributing to nociceptor sensitization and pain development.
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关键词
CGRP,DRG,EG-VEGF,PKRs,PNS,TRPA1,WT,ANOVA,CFA,CNS,GPCR,MIT-1,MO,PKs,PROK1,PROK2,PKR1,PKR2,PWT,TRPV1
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