Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl)benzothiazole derivatives as potential antioxidant, antibacterial and antitumor agents.

Livio Racané,Lucija Ptiček,Glorija Fajdetić,Vesna Tralić-Kulenović,Marko Klobučar,Sandra Kraljević Pavelić,Mihaela Perić,Hana Čipčić Paljetak,Donatella Verbanac,Kristina Starčević

Bioorganic Chemistry（2020）

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摘要

•Novel 6-substituted-2-(2-hydroxy/methoxyphenyl)benzothiazoles.•Newly developed green synthesis for substitution on 2-arylbenzothiazoles.•Selective and strong antiproliferative activity for 5b, 5c, 5e, 5f and 6f.•5f and 6f showed pronounced antioxidative properties.•5f and 6f showed significant modulation of the hypoxia signalization through HIF-1α.

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关键词

Green synthesis,Benzothiazoles,Antitumor activity,Antibacterial activity,Antioxidative activity,HIF-1 protein

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