Phosphorescent iridium(III) complex for efficient sensing of hypochlorite and imaging in living cells.

In consideration of the strong oxidizing power of hypochlorite (ClO−), which could cleave CN moiety, a cyclometalated iridium (III) complex (Ir-Ts) modified hydrazide group as the response unit was synthesized to sensitively and selectively detect ClO− under neutral condition. Upon addition of ClO−, a 21-fold emission enhancement at 574 nm was observed and phosphorescent product was formed due to the cleavage of CN moiety. The probe Ir-Ts displayed rapid response (<15 s) and high selectivity toward ClO− with a low detection limit of 86 nM. More importantly, bioimaging of ClO− was further studied in living cells.