Genetic and Pharmacological Inactivation of Astroglial Connexin 43 Differentially Influences the Acute Response of Antidepressant and Anxiolytic Drugs.

Astroglial connexins (Cxs) 30 and 43 are engaged in gap junction and hemichannel activities. Evidence suggests that these functional entities contribute to regulating neurotransmission, thereby influencing brain functions. In particular, preclinical and clinical findings highlight a role of Cx43 in animal models of depression. However, the role of these proteins in response to currently available psychotropic drugs is still unknown.