PRMT7 promotes the growth of renal cell carcinoma through modulating the β-catenin/C-MYC axis.

Fei Liu, Lisong Wan,Haibin Zou,Zhengyue Pan,Wanming Zhou,Xiongbing Lu

The International Journal of Biochemistry & Cell Biology（2020）

引用 23|浏览20

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摘要

•PRMT7 was overexpression in renal cell carcinoma.•PRMT7 promoted RCC cell growth in a C-MYC dependent manner.•PRMT7 regulated C-MYC expression by modulating β-catenin expression.•PRMT7 methylated β-catenin to stabilize its expression.

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关键词

PRMT7,β-catenin,C-MYC,Renal cell carcinoma

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