Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs.

Jinmeng Zhao,Xinyi Niu,Jinjin Yu,Xin Xiao,Wenqi Li,Lulu Zang,Zhen Hu,Paul Siu-Po Ip,Weifeng Li

International Immunopharmacology（2020）

引用 53|浏览9

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摘要

•PCP suppresses ox-LDL-induced oxidative stress and inflammation in VSMCs.•PCP inhibits the conversion of VSMCs into foam cell and intracellular lipid accumulation.•PCP inhibits the expression of LOX-1, iNOS and COX-2.•PCP promotes the activation of ERK activated Nrf2/HO-1 signaling pathway in VSMCs.

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关键词

Poria cocos polysaccharides,Vascular smooth muscle cells,Inflammation,Oxidative stress,Foam cell,Nrf2/HO-1

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