Immunohistochemical localization of alpha-synuclein in the retina of some nocturnal and diurnal animals.

Although alpha-synuclein has been reported to participate in neurodegenerative diseases, the actual normal biological function of alpha-synuclein remains unclear. I investigated the correlation of alpha-synuclein expression with nocturnal and diurnal activity for various species. Hematoxylin and eosin staining, periodic acid-Schiff's reaction (PAS) and immunohistochemistry of alpha-synuclein expression were performed for the retinas of diurnal, nocturnal, nocturnal with diurnal activity species. I found different intensity of alpha-synuclein expression in the retinal layers. I found alpha-synuclein expression in the outer segment of the photoreceptor layer in the diurnal studied species and absence of alpha-synuclein expression in the compartments of photoreceptor layer in the retina of nocturnal species. I found localization of alpha-synuclein in the inner and outer segments of photoreceptors of the retina of nocturnal with diurnal activity species. The retinas of diurnal animals exhibited glycogen in the paraboloid structure in the inner segment of the photoreceptor layer. The retinas of nocturnal and nocturnal with diurnal activity species were devoid of glycogen in the photoreceptor layer. I conclude that the function of alpha-synuclein is more related to diurnal than to nocturnal species.