Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain.

Christopher M Holton,Lauren C Strother,Isaac Dripps,Amynah A Pradhan,Peter J Goadsby,Philip R Holland

British journal of pharmacology（2020）

引用 24|浏览9

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摘要

These results support the development of specific ASIC3 or combined ASIC1/3 blockers for migraine-related pain and point to a potential role for ASIC-dependent NO-mediated attack triggering. This has key implications for migraine, given the major unmet need for novel therapeutic targets.

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关键词

Acid sensing ion channels,headache,migraine,pain

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