Functionalization of the Imidazo[1,2-A]pyridine Ring in Α-Phosphonoacrylates and Α-Phosphonopropionates Via Microwave-Assisted Mizoroki–Heck Reaction

A series of new phosphonocarboxylates containing an imidazo[1,2-a]pyridine ring has been synthesized via the microwave-assisted Mizoroki-Heck reaction. The efficient modification of the imidazo[1,2-a]pyridine ring has been achieved as late-stage functionalization, enabling and accelerating the generation of a library of compounds from a common precursor.