Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.

Ons Marsit,Marie-Annick Clavel, Claudia Côté-Laroche,Sandra Hadjadj,Marc-André Bouchard,Mark D Handschumacher,Marine Clisson,Marie-Claude Drolet,Marie-Chloé Boulanger,Dae-Hee Kim,J Luis Guerrero,Philipp Emanuel Bartko,Jacques Couet,Marie Arsenault,Patrick Mathieu,Philippe Pibarot,Elena Aïkawa,Joyce Bischoff,Robert A Levine,Jonathan Beaudoin

Journal of the American College of Cardiology（2020）

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摘要

In these animal models of AR, the presence of MI was associated with impaired adaptive valve growth and more functional mitral regurgitation, despite similar LV size and function. More pronounced extracellular remodeling was observed in mitral and tricuspid leaflets, suggesting systemic valvular remodeling after MI.

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关键词

aortic regurgitation,LV remodeling,mitral regurgitation,mitral valve,myocardial infarction

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