MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner.

Raffaella Spina,Dillon M Voss, Xiaohua Yang,Jason W Sohn,Robert Vinkler, Julianna Schraner,Anthony Sloan,Scott M Welford,Norbert Avril,Heather M Ames,Graeme F Woodworth,Eli E Bar

Neuro-oncology advances（2020）

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摘要

Our findings establish a novel role for MCT4 as a critical regulator of cellular deoxyribonucleotide levels and provide a new therapeutic direction related to MCT4 depletion in GBM.

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关键词

MCT4,glioma stem cells,hypoxia,pyrimidine,radiation

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