Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures

Proceedings of the National Academy of Sciences of the United States of America, pp. 4142-4151, 2020.

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Abstract:

Radiation damage limits the accuracy of macromolecular structures in X-ray crystallography. Cryogenic (cryo-) cooling reduces the global radiation damage rate and, therefore, became the method of choice over the past decades. The recent advent of serial crystallography, which spreads the absorbed energy over many crystals, thereby reducin...More

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