Berberine combined with cyclosporine A alleviates acute graft-versus-host disease in murine models.

Meng Wang,Jinglan Zhang,Huayan Zhao,Dingming Wan,Zhongxing Jiang

International Immunopharmacology（2020）

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摘要

•A therapeutic strategy for acute GVHD.•Berberine may alleviate inflammation of acute GVHD via NF-κB pathway.•The concomitant use of berberine and cyclosporine A is more potent for acute GVHD than berberine and cyclosporine A.

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关键词

Berberine,Cyclosporine A,Graft-versus-host disease (GVHD),Inflammation,Oxidative stress,Nuclear factor-κB (NF-κB) signaling

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