DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction.

Yanxia Liu,Xiaoxiang Tian, Shan Liu,Dan Liu,Yang Li,Meili Liu,Xiaolin Zhang,Chenghui Yan,Yaling Han

Redox Biology（2020）

引用 22|浏览96

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摘要

•Overexpression of DNMT3B but not DNMT1 or DNMT3A in HUVECs inhibits CREG expression.•The CREG promoter contains a key methylation CG site at +201/+202 bp.•GR-α can bind to the +201/+202 bp site to promote CREG transcription.•Blocking CREG methylation may represent a novel therapeutic approach to treat ox-LDL-induced atherosclerosis.

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关键词

Epigenetics,CREG,Atherosclerosis,Endothelium,Nitric oxide

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