Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.

Wessel F Theeuwes,Nicholas A M Pansters,Harry R Gosker,Annemie M W J Schols,Koen J P Verhees,Chiel C de Theije, Rick H P van Gorp,Marco C J M Kelders, Onne Ronda,Astrid Haegens,Alexander H V Remels,Ramon C J Langen

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2020）

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摘要

•C.A. GSK-3 decreases baseline expression of OXPHOS genes and PGC-1α constituents.•C.A. GSK-3 suppresses expression of regulators of proteolysis.•Soleus mass recovery after unloading does not require GSK-3 inactivation.•Recovery of soleus OXPHEN after unloading does not require GSK-3 inactivation.

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关键词

GSK-3,Skeletal muscle,Muscle mass,Oxidative phenotype,Unloading/reloading

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