Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades

•High expression of Sin1 is a novel biomarker for human prostate cancer.•Sin1 promotes cell viability and invasion by modulating mTORC2-AKT signaling and epithelial-to-mesenchymal transformation.•Sin1 expression is regulated by AR signaling transcriptionally in androgen-dependent prostate cancer cells.•Sin1 interacts with AR to regulate its transcriptional activity.