Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine

Nidhi Gupta
Nidhi Gupta
Hansa Regar
Hansa Regar
Vijay Kumar Verma
Vijay Kumar Verma
Dhaneswar Prusty
Dhaneswar Prusty

International journal of biological macromolecules, 2020.

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AdjuvantHuman vaccineImmune receptorTLR signaling

摘要

Human immune cell toll-like receptors (TLRs) provide a novel chance for the development of the vaccine adjuvant engaging TLR signaling. A library of peptides was developed and peptides structure was generated through homology modeling and refinement. Further, these peptides were subjected to receptor-ligand interaction study against human...更多

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