Synthetic Studies of Cystobactamids As Antibiotics and Bacterial Imaging Carriers Lead to Compounds with High in Vivo Efficacy

Giambattista Testolin,Katarina Cirnski,Katharina Rox,Hans Prochnow,Verena Fetz, Charlotte Grandclaudon,Tim Mollner, Alain Baiyoumy,Antje Ritter, Christian Leitner,Jana Krull,Joop van den Heuvel, Aurelie Vassort,Sylvie Sordello,Mostafa M. Hamed,Walid A. M. Elgaher,Jennifer Herrmann,Rolf W. Hartmann,Rolf Mueller,Mark Broenstrup

Chemical science（2020）

引用 17|浏览15

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摘要

Structure–activity relationship studies of the natural product cystobactamid at four different positions led to novel imaging probes and analogs with superior antibacterial activities and in vivo efficacy.

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