Molecular interactions of full-length and truncated GIP peptides with the GIP receptor – A comprehensive review
Peptides(2020)
摘要
•The N-terminus of GIP is essential for receptor activation.•The C-terminus of GIP has no apparent interaction with the GIP receptor.•C-terminal modifications of GIP has a minimal effect on receptor activation.•The absence of the c-terminus of GIP improves the antagonistic action for the GIP receptor.
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关键词
GIP(1-42),GIP receptor,Agonists,Antagonists
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