The Evaluation of HERV-K Env, Np9, Rec, Gag Expression in Normal, Polyp and Cancerous Tissues of Gastric and Colon

Aim: Gastrointestinal cancer is one of the most alarming cancers worldwide. Infections exert an impact on tumor progression in gastrointestinal tissues. The alteration in the expression of human endogenous retrovirus-K ( HERV-K) genes could remarkably induce oncogenic activity. Materials & methods: In 22 gastric and 23 colon cancer patients, the expression level of HERV-K env, rec, gag and np9 were evaluated. Results: While there was a slight increase in the expression of HERV-K env in colon cancer tissues, the expression level of this gene decreased in gastric tissues. Moreover, the expression of both np9 and gag HERV-K were upregulated only in colon cancer. Nevertheless, rec HERV-K was downregulated in gastric cancer tissues. Conclusion: HERV-K-associated genes can be used as a possible biomarker for cancers diagnosis.