Association of ABCB1 and VEGFA gene polymorphisms with breast cancer susceptibility and prognosis.

Adela Madrid-Paredes,Miguel Ángel Casado-Combreras,Cristina Pérez-Ramírez,Ana María Segura-Pérez,Clara Chamorro-Santos,Esther Vergara-Alcalde,Antonio Sánchez-Pozo,Miguel Ángel Calleja-Hernández,Marisa Cañadas-Garre

Pathology - Research and Practice（2020）

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摘要

Breast cancer (BC) is the most common cause of cancer-related death in women worldwide. Several ABCB1 and VEGFA gene polymorphisms, such as ABCB1-G1199 T/A (rs2229109), VEGFA -634 G > C (rs2010963), VEGFA 2578 C > A (rs699947) and VEGFA 7 C > T (rs25648) have been associated with risk of BC and clinical outcomes. The purpose of this study was to evaluate the association between these gene polymorphisms and BC risk and prognosis.

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关键词

Susceptibility,Prognosis,Breast cancer,Polymorphisms

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