Tumor-specific transcript variants of cyclin D1 in mantle cell lymphoma and multiple myeloma with chromosome 11q13 abnormalities.

Yoshiaki Chinen,Taku Tsukamoto,Saori Maegawa,Yayoi Matsumura-Kimoto,Tomoko Takimoto-Shimomura,Kazuna Tanba,Yoshimi Mizuno,Yuto Fujibayashi,Saeko Kuwahara-Ota,Yuji Shimura,Tsutomu Kobayashi,Shigeo Horiike,Masafumi Taniwaki,Junya Kuroda

Experimental Hematology（2020）

引用 3|浏览32

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摘要

•Mantle cell lymphoma and multiple myeloma with 11q13 abnormalities express Cyclin D1 transcript variants with longer 5′-UTRs.•Cyclin D1 transcript variants with longer 5′-UTRs encode normal-sized cyclin D1 protein.•Protein expression of the CCND1 transcript variants with longer 5′-UTRs is regulated by the mTOR/EIF4E pathway.

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