Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states

Timothy R Stachowski

Mary E Snell

Edward H Snell

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IUCRJ, pp. 238-252, 2020.

Cited by: 0|Views13

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Keywords:

latency-associated peptidetransforming growth factor beta-1growth factorsstructural biologyTGF beta-1

Abstract:

Transforming growth factor beta-1 (TGF beta-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGF beta-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically ...More

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