An Effective Biclustering-Based Framework for Identifying Cell Subpopulations From scRNA-seq Data
IEEE/ACM Transactions on Computational Biology and Bioinformatics(2021)
摘要
The advent of single-cell RNA sequencing (scRNA-seq) techniques opens up new opportunities for studying the cell-specific changes in the transcriptomic data. An important research problem related with scRNA-seq data analysis is to identify cell subpopulations with distinct functions. However, the expression profiles of individual cells are usually measured over tens of thousands of genes, and it r...
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关键词
Noise measurement,Data analysis,Gene expression,Clustering methods,Principal component analysis,Computational biology,Bioinformatics
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