Therapeutic effects of Wharton’s jelly-derived Mesenchymal Stromal Cells on behaviors, EEG changes and IGF-1 in rat model of the Parkinson’s disease

•The hyperalgesia, anxiety-like symptoms and EEG changes were increased significantly in both "PD+C and PD+C+D" groups.•The insulin-like growth factor 1(IGF-1) increased significantly in "PD+C and PD+C+D" groups.•The number of dopaminergic neurons were increased significantly in both " PD + C and PD+C+D " groups.•Treatment with combination of hWJ-MSCs and L-Dopa-Carbidopa can promise as a better strategy for improve the cognition disorders in PD.