Stimuli-Responsive Dual Drugs-Conjugated Polydopamine Nanoparticles For The Combination Photothermal-Cocktail Chemotherapy

We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm(2), 10 min), PDOXCBs gradually heated aqueous solution over 12.8-13.9 degrees C, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,1.-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT-CCT) treatment based on PDOXCB 27 plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC50) of 2.23 mu.g/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.