Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion.

Jiang Man,Kefei Cui,Xiaojie Fu,Di Zhang,Zhengfang Lu,Yufeng Gao,Lie Yu,Nan Li,Jianping Wang

Brain Research（2020）

引用 11|浏览18

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摘要

•We used 2VO procedure to mimic chronic cerebral hypoperfusion in rats.•Donepezil promoted SVZ neurogenesis and neurologic outcome in 2VO rats.•Donepezil upregulated Src and EGFR/FGFR pathway within SVZ in 2VO rats.•Src inhibitor KX-01 abolished neurogenesis and neuroprotective effects of donepezil.

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关键词

CCH,2VO,SVZ,NSCs,AchE,FGFR,EGFR,AchRs,BrdU,PVDF,TBST,GAPDH,PBS,DCX,DAPI,ChAT,GPCRs,PKC,HB-EGF

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