Prenatal NO 2 exposure and neurodevelopmental disorders in offspring mice: Transcriptomics reveals sex-dependent changes in cerebral gene expression.

Wei Yan,Huifeng Yue,Xiaotong Ji,Guangke Li,Nan Sang

Environment International（2020）

引用 19|浏览12

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摘要

•Prenatal NO2 exposure induces male-specific neurocognitive deficits in offspring.•Prenatal NO2 exposure induces sex-dependant transcriptomic profile changes in pups.•The male-specific neurological dysfunction is associated with hub lncRNAs modulation.

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关键词

Prenatal NO2 exposure,Spatial learning and memory,mRNA and long noncoding (lncRNA) expression profiles,Apolipoprotein E (ApoE),Metastasis-associated lung adenocarcinoma transcript 1 (Malat1)

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