The Treatment of Acute Rheumatic Fever: Novel Use of Hydroxychloroquine.

Nigel J Wilson, Anthony Concannon,John Malcolm,Sarka Davidakova,William John Martin,Rachel Webb, Nicole J Moreland

PEDIATRIC INFECTIOUS DISEASE JOURNAL（2020）

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摘要

Hydroxychloroquine (HCQ) suppresses an interleukin-1 beta-granulocyte-macrophage colony-stimulating factor cytokine axis, reported to be dysregulated in peripheral blood mononuclear cells of acute rheumatic fever patientsex vivo. We describe HCQ treatment for 2 patients with rheumatic carditis and a protracted inflammatory course. HCQ was associated with control of inflammatory markers, control of pericarditis in first patient and stabilization of progressive carditis in the second patient.

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关键词

rheumatic fever,rheumatic heart disease,hydroxychloroquine,corticosteroids,GM-CSF

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