Network neuroscience of apathy in cerebrovascular disease.

Jonathan Tay,Danuta M. Lisiecka-Ford,Matthew J. Hollocks,Anil M. Tuladhar,Thomas R. Barrick,Anne Forster,Michael J. O’Sullivan,Masud Husain,Frank-Erik de Leeuw,Robin G. Morris,Hugh S. Markus

Progress in Neurobiology（2020）

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摘要

•A network-based model may be able to describe apathy in cerebrovascular disease.•Focal network damage, such as in stroke, could lead to network failure and apathy.•Changes to remote regions or network disconnection can lead to apathy over time.•Specific subnetworks may underlie motivation-related cognitive functioning.•Understanding the network basis of apathy could lead to targeted treatments.

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SVD,GDB,WMH,PFC,ACC,OFC,SMA,NAA,rCBF,DTI,FA,rTMS,CADASIL,CRP,TMT-B,BMI

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