CD4+ T cell phenotypes in the pathogenesis of immune thrombocytopenia

•Platelet specific CD4+ T cells are required for anti-platelet antibody production.•Th1/Th2 immune deviation is directly implicated in ITP development and progression.•Th17 cells and platelets have multifaceted and pro-active mutual relationship.•Both numerical and functional abnormalities of Tregs were observed in ITP patients.•Th22, Th9 and Tfh cells could be also associated with ITP pathophysiology.