Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.

Xiaoyu Qu,Huan Gao,Jinghui Zhai,Jingmeng Sun,Lina Tao,Yueming Zhang,Yanqing Song,Tingting Hu

European Journal of Pharmaceutical Sciences（2020）

引用 18|浏览4

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摘要

•AS IV could enhance the chemosensitivity of cisplatin in HepG2 cells.•AS IV could enhance anti-tumor effect of cisplatin in H22 tumor-bearing mice.•AS IV may play the role of chemosensitivity by supressing MRP2 in tumor cells.•MRP2 in mice kidneys were not altered and not influenced in kidney function.

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关键词

Cisplatin,Astragaloside IV,Multidrug resistance-associated protein 2,Chemosensitivity,Hepatocellular carcinoma

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