Reconstruction of nano-flares based on Au-Se bonds for high-fidelity detection of RNA in living cells.

We have, for the first time, developed a Au-Se-DNA nanoprobe by upgrading the conventional Au-S bonds of nano-flares to more stable Au-Se bonds for high-fidelity imaging of target RNAs in living cells. The design concept is potentially introduced into various Au-DNA nanosensors that offer wide application prospects in research and clinical practice.