First Analog of Pyrimidine Nucleosides with Two D-Ribofuranose Residues

R. R. Sharipova,L. F. Saifina, M. G. Belenok,V. E. Semenov,V. E. Kataev

Russian Journal of Organic Chemistry（2020）

引用 3|浏览12

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摘要

The reaction of 1,3-bis(pent-4-yn-1-yl)-6-methyluracil with 2,3,5-tri- O -acetyl-β-D-ribofuranosyl azide gave 1,3-bis{3-[1-(2,3,5-tri- O -acetyl-β-D-ribofuranosyl)-1 H -1,2,3-triazol-4-yl]propyl}-6-methyluracil which was deprotected by treatment with a solution of sodium methoxide in methanol to obtain 1,3-bis{3-[1-(β-D-ribofuranosyl)-1 H -1,2,3-triazol-4-yl]propyl]-6-methyluracil as a first analog of pyrimidine nucleosides containing two D-ribofuranose fragments.

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关键词

nucleosides, nucleoside analogs, uracil, [3+2]-cycloaddition, click chemistry, 1,2,3-triazoles

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