An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective

•This is the first study evaluating HCC guidelines using AGREE II method, from the radiation oncologists’ perspective.•In our evaluation, four guidelines from the NCCN, EASL, AASLD, and KLCSG were deemed applicable without modification.•All domains except “Scope and Purpose” (63.9%) and “Clarity of Presentation” (65.7%) had median scores <50%, and “Applicability” (36.1%) domain had the lowest score.•Future guidelines should emphasize more of “Applicability,” as modern HCC treatment requires multidisciplinary approaches involving up-to-date techniques and systemic agents.