Detrimental Effects Of Donor Brain Death On Tolerance Induction May Be Eliminated By Delaying Mixed Chimerism In Non-Human Primates

J. M. O,W. Sommer,K. Ahrens,P. Patel,D. Becerra,J. Morrissette,T. Costa,K. Pruner,J. Paster,A. Bean,A. Dehnadi,I. Hanekamp,I. Rosales,R. Smith,R. Colvin,G. Benichou,J. Allan,T. Kawai,J. Madsen

JOURNAL OF HEART AND LUNG TRANSPLANTATION（2020）

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摘要

Donor brain death negatively impacts tolerance induction after mixed chimerism conditioning leading to a higher incidence of allograft rejection. Delaying recipient conditioning and DBMT might eliminate the detrimental effects of donor brain death and its associated pro-inflammatory side-effects, thus increasing the chance of long-term tolerance.

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donor brain death,mixed chimerism,nonhuman primates,tolerance induction

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