Curcumin Regulates the r(CGG) exp RNA Hairpin Structure and Ameliorate Defects in Fragile X-Associated Tremor Ataxia Syndrome
Frontiers in neuroscience, pp. 2952020.
CGG repeatFXTASRAN translationsplicing defectstherapeuticsMore(1+)
Fragile X-associated tremor ataxia syndrome is an untreatable neurological and neuromuscular disorder caused by unstable expansion of 55-200 CGG nucleotide repeats in 5' UTR of Fragile X intellectual disability 1 () gene. The expansion of CGG repeats in the mRNA elicits neuronal cell toxicity through two main pathogenic mechanisms. First...More
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