Curcumin Regulates the r(CGG) exp RNA Hairpin Structure and Ameliorate Defects in Fragile X-Associated Tremor Ataxia Syndrome

Arun Kumar Verma
Arun Kumar Verma
Eshan Khan
Eshan Khan
Subodh Kumar Mishra
Subodh Kumar Mishra
Nicolas Charlet-Berguerand
Nicolas Charlet-Berguerand

Frontiers in neuroscience, pp. 2952020.

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Keywords:
CGG repeatFXTASRAN translationsplicing defectstherapeuticsMore(1+)

Abstract:

Fragile X-associated tremor ataxia syndrome is an untreatable neurological and neuromuscular disorder caused by unstable expansion of 55-200 CGG nucleotide repeats in 5' UTR of Fragile X intellectual disability 1 () gene. The expansion of CGG repeats in the mRNA elicits neuronal cell toxicity through two main pathogenic mechanisms. First...More

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