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Curcumin Regulates the r(CGG) exp RNA Hairpin Structure and Ameliorate Defects in Fragile X-Associated Tremor Ataxia Syndrome.

FRONTIERS IN NEUROSCIENCE, (2020): 295

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Abstract

Fragile X-associated tremor ataxia syndrome is an untreatable neurological and neuromuscular disorder caused by unstable expansion of 55-200 CGG nucleotide repeats in 5 ' UTR of Fragile X intellectual disability 1 (FMR1) gene. The expansion of CGG repeats in the FMR1 mRNA elicits neuronal cell toxicity through two main pathogenic mechanis...More

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Author
Arun Kumar Verma
Arun Kumar Verma
Eshan Khan
Eshan Khan
Subodh Kumar Mishra
Subodh Kumar Mishra
Nicolas Charlet-Berguerand
Nicolas Charlet-Berguerand
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