Evolutionary landscapes of Pseudomonas aeruginosa towards ribosome-targeting antibiotic resistance depend on selection strength

•The width of the sublethal selection window depends on the selective antibiotic.•Selection strength affects the evolution landscape of tigecycline resistance in Pseudomonas aeruginosa.•Sublethal concentrations of antibiotics select multi-drug-resistant bacteria.•Cross-resistance of antibiotic-resistant mutants is decoupled from selection strength.•Antibiotic pollution can be a risk for selecting multi-drug-resistant bacteria.