Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model.
Stem Cell Research(2020)
摘要
•Injection of uroplakin3a could generate feasible interstitial cystitis rat model with clinical symptoms and signs, such as bladder pain, overactivity and inflammatory changes of bladder.•Injection of adipose tissue-derived mesenchymal stem cell into bladder submucosa had functional and histological therapeutic effects in an interstitial cystitis rat model.•Combination therapy with mesenchymal stem cell and pentosan polysulfate had synergic effects in the interstitial cystitis rat model, resulting in improved intercontraction interval, reduced bladder fibrosis, and decreased inflammatory proteins.
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关键词
Interstitial cystitis,Rats,Stem cells,Pentosan polysulfate sodium
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