Assessment of conditioned fear extinction in male and female adolescent rats.
Psychoneuroendocrinology(2020)
摘要
•Adolescent female rats in proestrus or met/diestrus at extinction show impaired extinction compared to males, immature females and females in estrus on extinction day.•Adolescent female rats in met/diestrus at extinction day showed impaired extinction recall compared to males when tested 24 hours later.•Gonadectomy improves extinction in adolescent female rats, whereas male rats show impaired extinction when compared to rats that received sham surgery.•These effects are opposite to those seen in adult female rats, which suggests that the influence of estrous cycle on extinction of conditioned fear is age-dependent.
更多查看译文
关键词
freezing,extinction,adolescence,sex difference,estradiol,gonadectomy
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络