Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells.

Elena Navarro-Villarán,Patricia de la Cruz-Ojeda,Laura Contreras,Raúl González,María Negrete,María A Rodríguez-Hernández,Luís M Marín-Gómez,José M Álamo-Martínez, Antonio Calvo,Miguel A Gómez-Bravo,Jesús de la Cruz,Javier Padillo,Jordi Muntané

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）

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摘要

The more potent pro-apoptotic and anti-proliferative properties of Tacrolimus versus mTOR inhibitors were associated with an increased activation of PERK and p53 signaling, and p21 protein expression. FKBP12 and FKBP51 appeared to be the most relevant partners of Tacrolimus and mTOR inhibitors exerting a pro-survival effect in HepG2 cells. The observed effects of immunosuppressants were related to a specific miRNA signature in liver cancer cells.

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关键词

Apoptosis, Autophagy, Endoplasmic reticulum stress, Immunosuppressants, Hepatocarcinoma

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