TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment

Qianshuo Liu
Qianshuo Liu
Lu Zhu
Lu Zhu
Jian Zheng
Jian Zheng
Xuelei Ruan
Xuelei Ruan
Shuo Cao
Shuo Cao

RNA biology, pp. 1-16, 2020.

Cited by: 0|Views21
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Abstract:

The blood-brain barrier (BBB) plays a pivotal role in the maintenance and regulation of the neural microenvironment. The BBB breakdown is a pathological change in early Alzheimer's disease (AD). RNA-binding proteins (RBPs) and long non-coding RNAs (lncRNAs) are involved in the regulation of BBB permeability. Our study demonstrates the rol...More

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