In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

Ryan S O'Dell
Ryan S O'Dell
Tyler A Godek
Tyler A Godek
Joanna E Harris
Joanna E Harris
Hugh H Bartlett
Hugh H Bartlett
Wenzhen Zhao
Wenzhen Zhao
Brent C Vander Wyk
Brent C Vander Wyk

Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020.

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Keywords:
Alzheimer's diseaseSV2A[11C]UCB-J | PETsynaptic density

Abstract:

We were able to measure widespread synaptic loss due to AD using [ C]UCB-J PET. Future studies will continue to evaluate the utility of SV2A PET for tracking AD progression and for monitoring potential therapies.

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