Cantharidin treatment inhibits hepatocellular carcinoma development by regulating the JAK2/STAT3 and PI3K/Akt pathways in an EphB4-dependent manner.

Man Zhu,Xianpeng Shi,Zhengyan Gong,Qi Su,Runze Yu,Bo Wang,Tianfeng Yang,Bingling Dai,Yingzhuan Zhan,Dongdong Zhang,Yanmin Zhang

Pharmacological Research（2020）

引用 31|浏览11

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摘要

Cantharidin suppressed HCC cell growth and induced intrinsic cell apoptosis by targeting EphB4, which inhibited a novel target, the downstream JAK2/STAT3 pathway, and the previously known target, the PI3K/Akt signaling.

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关键词

HCC,EphB4,CTD,JAK,STAT,PI3K,Bcl-2

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